Doctoral Students
Work Package 1 - Ultrasound & Solid Nanoparticles for Viral Delivery (WP1)

Megan Grundy

Supported by the Clarendon Fund, Megan joined the BUBBL group in October 2014 and is co-supervised by Professors Robert Carlisle and Constantin Coussios. Megan is working to enhance the ultrasound-mediated delivery of biologic cancer therapeutics. Her research looks at using chemical surface modification of oncolytic viruses and antibodies in order to increase their density and improve their circulation kinetics. Megan graduated from McGill University in Montreal, Canada in 2013 with a Bachelor's degree in Physics and Physiology. Throughout her undergraduate degree, she conducted research at both the University of Calgary and McGill University in topics ranging from cardiac and respiratory physiology to neuromuscular modelling.
Claudia Hill
Claudia Hill

Claudia joined BUBBL under the supervision of Professor Robert Carlisle upon completion of her MEng in General Engineering at the University of Oxford. She is currently a first year DPhil student working on modifying oncolytic viruses for their enhanced delivery with ultrasound within Work Package 1 of OxCD3 . Specifically, Claudia is looking at using polymers to coat Vaccinia virus to improve its systemic delivery, and using ultrasound to improve its overall tumour penetration and distribution.
Prateek Katti

Prateek is a MD-PhD student and NIH Oxford-Cambridge Scholar, completing his graduate-entry medical training at the University of North Carolina at Chapel Hill and his D. Phil at the University of Oxford as sponsored by the National Institutes of Health (NIH, USA Government). At Oxford and within Work Package One (WP1), he is working at the interface of medical engineering and onco-immunotherapy, aiming to enhance ultrasound-mediated intratumoral delivery of immunotherapeutic antibodies to potentiate anti-tumor immunity. He is co-advised by Prof. Constantin Coussios and Prof. Robert Carlisle along with supervision by prominent investigators from Oxford’s Nuffield Department of Surgical Sciences (NDS) and the NIH.  Prateek attended the Commonwealth Honors College of the University of Massachusetts. Within four years he earned B.S. degrees in Chemical Engineering and Biochemistry & Molecular Biology and was inducted into Tau Beta Pi. He graduated summa cum laude in both disciplines and completed an interdisciplinary honors thesis exploring the mechanical cues of breast cancer tumorigenesis under the direction of Prof. Alfred Crosby and Prof. Shelly Peyton. 
Cameron Smith

Cameron graduated from Imperial College London with first class honours in Biomedical Engineering (MEng).  His final year project was under the supervision of Dr James Choi, developing an acoustic monitoring technique to allow for the measurement of the velocity distribution of microbubbles. As a OxCD3-funded University of Oxford doctoral student, Cameron's current work explores real time monitoring of ultrasound mediated drug delivery. It is hoped that his work will allow for improved monitoring of ultrasound therapies making it easier to bring them to a clinical setting.
Work Package 2: US-triggered liposomes for the delivery of radiopharmaceuticals

Irini Skaripa-Koukelli

Irini graduated from King’s College London in 2014 with a Master’s in Pharmacy (MPharm) degree. Throughout this course, she undertook a summer research project in medicinal chemistry as well as a final year project on the fabrication and characterisation of biodegradable polymeric nanoparticles for drug delivery.  Irini graduated from the National and Kapodistrian University of Athens in 2011 with a Bachelor’s degree in Chemistry. For this course, she worked in organic chemistry and biochemistry labs. Supported by the EPSRC OxCD3 grant, Irini joined the Department of Oncology in October 2015 to undertake a DPhil project co-supervised by Professors Katherine Vallis and Robert Carlisle from the Institute of Radiation Oncology and BUBBL, respectively. Her project is aimed at exploiting the lactate shuttling through the monocarboxylate transporter for ultrasound-triggered targeted radiotherapy (TRT). Irini is a graduate student at St Cross college.
Jamie Wallis

Jamie graduated from the University of Essex in 2015 with a First class Honours degree in Mathematical sciences including a year abroad at the University of New Mexico, USA. He completed a final year project titled “Analysis of discrete-time biased and correlated random walks” under the supervision of Professor Edward Codling. In September 2015, Jamie then joined the University of Oxford on the Synthetic Biology Doctoral Training Programme.  In October 2016, Jamie joined the BUBBL group as a DPhil candidate, under the supervision of Professor Robert Carlisle and Professor Len Seymour in Oncology, continuing his research into the development of synthetic vaccines.
Work Package 3: Shock wave delivery of antibody fragments

Joseph Blackmore
Joseph Blackmore

Joe graduated from University of Oxford with a MEng in Mechanical Engineering in 2014. As part of his undergraduate degree, he completed research projects on the focusing of shockwaves using parabolic reflectors and the development of a film-cooling hole for application to gas turbines. He was also awarded the Institute of Mechanical Engineers (IMechE) Best Student Certificate. Later in 2014, Joe joined the Life Sciences Interface Doctoral Training Centre and participated in two master’s level projects.  One on the application of high-intensity focused ultrasound (HIFU) to the brain and the other on the effect of sheets in cardiac electromechanics. In October 2015, Joe joined the BUBBL group as a DPhil candidate under the supervision of Professor Robin Cleveland to continue research into the delivery of ultrasound to the brain. His research centres on the propagation of ultrasound through the skull to target specific brain locations for a range of therapeutic applications including thermal ablation, blood brain barrier opening and neuromodulation
Alexander Martin

Alex graduated from Ulster University, in Northern Ireland, in 2017 with a BSc (Hons) Biomedical Engineering degree with Diploma in Professional Practice, first class honours and distinction, respectively.  Over the course of his degree he performed research in electrochemistry based sensor devices and for his dissertation, researched and developed Microneedle arrays for drug delivery and sensing applications under the super vision of Professor James Davis. As well as research, Alex completed a 15 month industry placement, working in the medical device industry with Negative Pressure Wound Therapy devices. He experienced working with regulatory bodies and was part of teams bringing devices back to market. Receiving the Oxford Centre for Drug Delivery Devices studentship, Alex joined BUBBL and Wadham College as a DPhil candidate in October 2017 and is under the supervision of Professor Robin Cleveland and Professor Robert Carlisle. The main focus of his research will be in the delivery of cancer therapeutics using ultrasound and shock waves.  
Work Package 4: siRNA Delivery for Targeted Imaging and Therapy of Brain Metastases

Miles Aron

Miles is a DPhil student under the supervision of Professor Eleanor Stride. During his Fulbright year he investigated the role of mechanical stimuli in blood-brain barrier opening by focused ultrasound and microbubbles. Miles is continuing research on the cellular mechanisms behind ultrasound-based therapies with a focus on translation to targeted and non-invasive drug delivery to the brain. Miles Aron graduated summa cum laude from the University of Hartford with a BSE in Acoustical Engineering in 2013 after completing internships at both the US Department of Energy at the SLAC National Accelerator Laboratory and at NASA Ames Research Centre among others.    
Luke Richards

Luke  graduated the University of Oxford with an MEng in general engineering. Projects in Luke's undergraduate degree included a study of how HIFU could be used to occlude a major artery, and development of a device to manipulate magnetic nanoparticles. Luke began his DPhil in October 2016 under the supervision of Eleanor Stride and Robin Cleveland. Luke is part of an OxCD3 project to improve drug delivery to brain metastases, and is interested in the effective use of low intensity ultrasound in the human brain and skull.
Oliver Vince

Oliver holds a MEng from the University of Oxford's Engineering Science department. He joined the Oxford Centre for Drug Delivery Devices in October 2016 under the supervision of Professor Stride. He is currently continuing the work that he began in his Master’s project; he will be further developing the clinical system and conducting a more comprehensive study on magnetic nanodroplet trapping. Oliver is also working on an in vitro brain phantom to improve our understanding of how the vasculature and other factors will affect targeted therapy of brain metastases. In another study, Oliver is investigating the relationships between sonoporation and the lipid packing order of cell membranes in an in vitro blood brain barrier model. For his Master’s Research Project, Oliver worked with Professor Eleanor Stride to analyse the theoretical and in vitro feasibility of magnetically, biochemically and acoustically targeting liquid nanodroplets in the cerebral cortex for the treatment of carotid artery stenosis and brain metastases. Oliver also developed a prototype system for controlling the position of a magnet and an ultrasound probe relative to the brain that was intended to be developed for future use in the clinic.


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