About

People

  1. The Team
  2. Director
  3. Investigators
  4. Post-Doctoral Researchers
  5. Steering Committee
  6. International Advisory Board
  7. Centre Administration
  8. Doctoral Students

Partners

  1. EPSRC
  2. Industry - Medical Devices
  3. Industry - Pharmaceuticals
  4. Industry - Measurement & Testing
  5. GMP Manufacturing

Publications

Clinical Trials

  1. TarDox

Contact

Publications


Hill, C., Grundy, M., Bau, L., Wallington, S., Balkaran, J., Ramos, V., Fisher, K., Seymour, L., Coussios, C., Carlisle, R.  Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus  Molecular Therapy — Oncolytics 21:47-61 (2021)
Vince, O., Peeters, S., Johanssen, V., Gray, M., Smart, S., Sibson, N., Stride, E.  Microbubbles containing lysolipid enhance ultrasound mediated blood-brain-barrier breakdown in vivo  Advanced Healthcare Materials  DOI: 10.1002/adhm.202001343 (2020)
Versluis, M., Stride, E., Lajoinie, G., Dollet, B., Segers, T.  Ultrasound Contrast Agent Modelling: A Review.    Ultrasound in Medicine and Biology, 20(4), 1994:319-333 DOI: 10.1016/j.ultrasmedbio.2020.04.014 (2020)
Sander, T., Milicic, E., Stride, E.  Investigating the Effect of Encapsulation Processing Parameters on the Viability of Therapeutic Viruses.  Pharmaceutics 12 (4), 388 (2020)
Pereno, V., Lei, J., Carugo, D., Stride, E.   Microstreaming inside model cells induced by ultrasound and microbubbles.  Langmuir DOI: 10.1021/acs.langmuir.0c00536 (2020)
Sezgin, E., Carugo, D., Levental, I., Stride, E., Eggeling, C.  Creating Supported Plasma Membrane Bilayers Using Acoustic Pressure. Membranes  Membranes, 10(2), 30 (2020)
Stride, E., Segers, T., Lajoinie, G., Cherkaoui, S., Bettinger, T., Versluis, M.  Microbubble agents: New directions  Ultrasound in Medical & Biology, 46(6): 1326-1343 (2020)
Kooiman, K., Roovers, S., Langeveld, S., Kleven, R., Dewitte, H., O'Reilly, M., Escoffre, J., Bouakaz, A., Verweij, M., Hynynen, K., Lentacker, I., Stride, E., Holland, C.  Ultrasound-responsive cavitation nuclei for therapy and drug delivery  

Ultrasound in Medicine & Biology. 46(6):1296-1325 (2020)

Parhizkar, M., Reardon, P., Harker, A., Browning, R., Stride, E., Pedley, R., Knowles, J., Edirisinghe, M.  Enhanced efficacy in drug-resistant cancer cells through synergistic nanoparticle mediated delivery of cisplatin and decitabine.  Nanoscale Advances, 2, 1177- 1186 (2020)
Browning, R., Aron, M., Booth, A., Rademeyer, P., Wing, S., Brans, V., Shrivastava,S., Carugo, D., Stride, E.  Spectral Imaging for Microbubble Characterization  Langmuir, 36 (2), 609-617 (2020)
Shieh, B., Stride, E.  Development of a CMUT model for non-linear actuation and contact dynamics  IEEE International Ultrasonics Symposium (IUS), 754-757 (2019)  
Owen, J., Thomas, E., Menon, J., Gray, M., Skaripa-Koukelli, I., Gill, M., Wallington, S., Miller, R., Vallis, K., Carlisle, R.  Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation  Journal of Controlled Release, 319, 222-233 (2020)
Beguin, E., Gray, M. D., Logan, K. A., Nesbitt, H., Sheng, Y., Kamila, S., Barnsley, L., Bau,L., McHale, A.P., Callan, J.F., Stride, E.  Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device  Journal of Controlled Release, 317, 23-33 (2020)
Roovers, S., Deprez, J., Priwitaningrum, D., Lajoinie, G., Rivron, N., Declercq, H., D Wever, O., Stride, E., Le Gac, S., Versluis, M., Prakash, J., De Smedt, S.C., Lentacker, I.  Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound  Journal of Controlled Release, 316, 79-92.(2019)
Stride, E., & Coussios, C.  Nucleation, mapping and control of cavitation for drug delivery  Nature Reviews Physics. doi:10.1038/s42254-019-0074-y (2019)
Beguin, E., Shrivastava, S., Dezhkunov, N. V., McHale, A. P., Callan, J. F., & Stride, E.   Direct Evidence of Multibubble Sonoluminescence Using Therapeutic Ultrasound and Microbubbles  ACS Applied Materials & Interfaces, 11(22), 19913-19919. doi:10.1021/acsami.9b07084 (2019)
Jarrett, D., Stride, E., Vallis, K., & Gooding, M. J.  Applications and limitations of machine learning in radiation oncology  The British Journal of Radiology, 92(1100), 20190001. doi:10.1259/bjr.20190001 (2019)
Mannaris, C., Bau, L., Grundy, M., Gray, M., Lea-Banks, H., Seth, A., . . . Coussios, C. C.  Microbubbles, Nanodroplets and Gas-Stabilizing Solid Particles for Ultrasound-Mediated Extravasation of Unencapsulated Drugs: An Exposure Parameter Optimization Study.  Ultrasound in Medicine & Biology, 45(4), 954-967. 2019 doi:10.1016/j.ultrasmedbio.2018.10.033 (2019)
Owen, J., Kamila, S., Shrivastava, S., Carugo, D., Bernardino de la Serna, J., Mannaris, C., . . . Stride, E.  The Role of PEG-40-stearate in the Production, Morphology, and Stability of Microbubbles  Langmuir. doi:10.1021/acs.langmuir.8b02516 (2019)
de Saint Victor, M., Barnsley, L. C., Carugo, D., Owen, J., Coussios, C. C., & Stride, E.  Sonothrombolysis with Magnetically Targeted Microbubbles.  Ultrasound in Medicine & Biology. doi:10.1016/j.ultrasmedbio.2018.12.014 (2019)
Beguin, E., Bau, L., Shrivastava, S., & Stride, E.  Comparing Strategies for Magnetic Functionalization of Microbubbles  ACS Applied Materials & Interfaces, 11(2), 1829-1840 (2019)
Zhang, J., Shrivastava, S., Cleveland, R. O., & Rabbitts, T. H.   Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves  ACS Applied Materials & Interfaces. doi:10.1021/acsami.8b21398 (2019)
Paverd, C., Lyka, E., Elbes, D., Coussios, C-C  Passive acoustic mapping of extravasation following ultrasound-enhanced drug delivery  Physics in Medicine & Biology, 64:4 (2019)
Gray, M. D., Lyon, P. C., Mannaris, C., Folkes, L. K., Stratford, M., Campo, L., . . . Coussios, C. C.  Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial    Radiology, 291(1):181445. doi:10.1148/radiol.2018181445 (2019)
Lyon, P., Winter, H., Herbschleb, K., Campo, L., Carlisle, R. Wu, F., Goldin, R., Coussios, C-C, Middleton, M., Gleeson, F., Boardman, P., and Sharma, R.  Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer  Radiology Case Reports, 13(6):1259 -1266 (2018)
Lyon, P., Gray, M., Mannaris, C., Folkes, L., Stratford, M., Campo, L., Chung, D., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M., Gleeson, F., Coussios, C-C.  Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial  The Lancet Oncology volume 19, Issue 8, August 2018, Pages 1027-1039
 
Ruan, J.-L., Hsu, J.-W., Browning, R. J., Stride, E., Yildiz, Y. O., Vojnovic, B., & Kiltie, A. E.   Mouse Models of Muscle-invasive Bladder Cancer: Key Considerations for Clinical Translation Based on Molecular Subtypes  European Urology Oncology. doi:10.1016/j.euo.2018.08.014 (2018)
Browning, R. J., & Stride, E.   Microbubble-Mediated Delivery for Cancer Therapy  Fluids, 3(4), 74. (2018)
Pereno, V., Aron, M., Vince, O., Mannaris, C., Seth, A., de Saint Victor, M., Mannaris, C., Lajoinie, G., Versluis, M., Coussios, C., Carugo, D., Stride, E.   Layered acoustofluidic resonators for the study of the physical and biological effects of acoustic cavitation   Biomicrofluidics 12, 034109 (2018)
Owen, J., Crake, C., Browning, R., Lee, J., Carugo, D., Stride, E.   A versatile method for the production of magnetic microbubbles for targeted drug delivery   Drug Deliv. and Transl. Res. 8: 342 (2018) 
Chad A. Tagge,Andrew M. Fisher,Olga V. Minaeva, Amanda Gaudreau-Balderrama, Juliet A. Moncaster,Xiao-Lei Zhang,Mark W. Wojnarowicz,Noel Casey, Haiyan Lu, Olga N. Kokiko-Cochran,Sudad Saman, Maria Ericsson,Kristen D. Onos, Ronel Veksler, Vlad Senatorov, Asami Kondo, Xiao Z. Zhou, Omid Miry, Linnea R. Vose, Katisha R. Gopaul, Chirag Upreti, Christopher J. Nowinski, Robert C. Cantu, Victor E. Alvarez, Janusz Konrad, James A. Hamilton, Ning Hua,Yorghos Tripodis, Andrew T. Anderson, Gareth R. Howell, Daniela Kaufer, Garth F. Hall, Kun P. Lu, Richard M. Ransohoff,Robin O. Cleveland,Neil W. Kowall,Bertrand R. Huber, Thor D. Stein, Bruce T. Lamb, William C. Moss, Alon Friedman, Patric K. Stanton, Ann C. McKee, Lee E. Goldstein  Concussion, Microvascular Injury, and Phosphorylated Tauopathy in Young Athletes after Impact Head Injury and an Impact Concussion Mouse Model  Brain 141:422-458 (2018)
Li, D., Pellegrino, A., Hallack, A., Petrinic, N., Jersalem, A., Cleveland, R.O.  Characterisation of single cell response to shock waves and in silico optimisation of shock wave-mediated therapy  Biophysical Journal 114:1433-1439 (2018). 
Suomi, V., Jaros, J., Treeby, B., Cleveland, R. O.  High-intensity focused ultrasound therapy in the kidney: a simulation study  IEEE Trans. on Biomedical Engineering 65: 969-979 (2018)
Barnsley, Lester C., Gray, Michael D., Beguin, Estelle, Carugo, Dario and Stride, Eleanor  A combined magnetic-acoustic device for simultaneous, co-aligned application of magnetic and ultrasonic fields.   Advanced Materials Technologies, 1-37. (2018)
Adams, Matthew T., Cleveland, Robin O., Roy, Ronald A.   A Modeling-Based Design and Assessment of an Acousto-Optic Guided High-Intensity Focused Ultrasound System  J. Biomed. Opt. 22(1), 017001 (2017)
Weissenbacher, A., Lo Faro, L., Boubriak, O., Soares, M., Roberts, I. S., Hunter, J., Voyce, D., Mikov, N., Cook, A., Ploeg, R.,Coussios,C-C., Friend, P.   Twenty‐four–hour normothermic perfusion of discarded human kidneys with urine recirculation  American Journal of Transplantation, 19(1), 178-192. (2018)
Cui, HW., Devlies, W, Stevens, DJ, Ravenscroft, S, Heers,H., Freidin, A., Cleveland, RO, Turney, BW.  CT Texture Analysis of Renal Stones Predicts Ease of Fragmentation with Shock Wave Lithotripsy  J Endourol. 31:694-700 (2017).
Zhang, L., Zhang, Z., Jasa, J., Li, D., Cleveland, R.O., Negahban, M., and Jérusalem, A.  Molecular dynamics simulations of heterogeneous cell membranes in response to uniaxial membrane stretches at high loading rates  Sci Rep. 2017 Aug 16;7(1):8316
V. Pereno, D. Carugo, L. Bau, E. Sezgin, J. Bernardino de la Serna, C. Eggeling, E. Stride.   Electroformation of giant unilamellar vesicles on stainless steel electrodes.   ACS Omega 2: 994-1002 (2017)
Lee, J., Crake, C., Teo, B., Carugo, D., de Saint Victor, M., Seth, A., Stride, E.,    Ultrasound-enhanced siRNA Delivery Using Magnetic Nanoparticle-loaded Chitosan-deoxycholic acid Nanodroplets.   Advanced Healthcare Materials 6 (8), 2192 - 2659 (2017)
Crake, C., Owen, J., Smart, S., Coviello, C.,  Coussios, C-C., Carlisle,R., Stride, E.,   Enhancement and Passive Acoustic Mapping of Cavitation from Fluorescently Tagged Magnetic Resonance-Visible Magnetic Microbubbles In Vivo  Ultrasound in Medicine & Biology 42 12: 3022 -3036 (2016)
Lea-Banks, H., Teo, B., Stride, E., Coussios, C-C.,   The Effect of Particle Density on Ultrasound-Mediated Transport of Nanoparticles  Phys. Med. Biol. 61 (22), 7906-7918 (2016).
 Bhatnagar, S., Kwan, J.J, Shah, A.R., Coussios, C-C., Carlisle, R.,   Exploitation of sub-micron cavitation nuclei to enhance ultrasound-mediated transdermal transport and penetration of vaccines  Journal of controlled release : official journal of the Controlled Release Society, 238 (2016) 22-30.
Owen J, McEwan C, Nesbitt H, Bovornchutichai P, Averre R, Borden M, et al.   Reducing Tumour Hypoxia via Oral Administration of Oxygen Nanobubbles.   (2016) PLoS ONE 11(12): e0168088. 
Suomi, V. , Han, Y. , Yang, D. , Edwards, D., Konofagou, E,  Cleveland, R.O.  The effect of temperature dependent tissue parameters on acoustic radiation force induced displacements  Physics Medicine Biology 61:7427–7447 (2016)
Nwokeoha, S., Carlisle, R., Cleveland, R.  The Application of Clinical Lithotripter Shock Waves on RNA Nucleotide Delivery to Cells.   Ultrasound in Medicine and Biology 42 10: 2478-2492 (2016).
Myers, R., Coviello, C., Erbs,  P., Rowe,  C., Kwan,   J., Foloppe,  J., Crake,  C, Finn,  S., Jackson, E. , Balloul, J.-M., Story, C., Coussios, C.-C. and Carlisle, R.   Polymeric Cups for Cavitation Mediated Delivery of Oncolytic Vaccinia Virus.  Molecular Therapy 24(9): 1627–1633 (2016)
Tedcastle, A., Illingworth, S., Brown, A., Seymour, L.W., Fisher, Kerry D.,  Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth  Molecular Therapy, 24 4: 796 - 804 (2016)
Grundy, M., Coussios, C.-C. Carlisle, R.  Advances in systemic delivery of anti-cancer agents for the treatment of metastatic cancer.  Expert Opin. Drug Deliv.1-15 (2016).


 

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